GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs9473555 | 1 | rs6458694 | chr6:49445306 | MUT | chr6:49398994-49431031:- | 0.34 | 5.63 | 8.58E-8 | Folate pathway vitamin levels |
| UCEC | cis | rs4237643 | 1 | rs6485438 | chr11:43686618 | HSD17B12 | chr11:43702143-43878160:+ | -0.37 | -4.46 | 1.59E-5 | Forced vital capacity |
| UCEC | cis | rs4237643 | 1 | rs6485443 | chr11:43696316 | HSD17B12 | chr11:43702143-43878160:+ | 0.37 | 4.59 | 9.27E-6 | Forced vital capacity |
| UCEC | cis | rs2028299 | 1 | rs6496609 | chr15:90379632 | AP3S2 | chr15:90373832-90456222:- | -0.43 | -4.39 | 2.11E-5 | Type 2 diabetes |
| UCEC | cis | rs6545883 | 1 | rs6545883 | chr2:61772257 | C2orf74 | chr2:61372243-61391964:+ | 0.43 | 4.49 | 1.38E-5 | Tuberculosis |
| UCEC | cis | rs9309473 | 1 | rs6546835 | chr2:73664715 | ALMS1P | chr2:73872046-73912692:+ | 0.55 | 6.51 | 1.02E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6546836 | chr2:73677833 | ALMS1P | chr2:73872046-73912692:+ | 0.52 | 6.14 | 6.72E-9 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6546837 | chr2:73677898 | ALMS1P | chr2:73872046-73912692:+ | 0.56 | 6.73 | 3.21E-10 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6546838 | chr2:73679280 | ALMS1P | chr2:73872046-73912692:+ | 0.55 | 6.58 | 7.18E-10 | Metabolite levels |
| UCEC | cis | rs9309473 | 1 | rs6546839 | chr2:73680508 | ALMS1P | chr2:73872046-73912692:+ | 0.57 | 6.81 | 2.1E-10 | Metabolite levels |
| UCEC | cis | rs568617 | 1 | rs656980 | chr11:65656282 | CTSW | chr11:65647284-65651212:+ | -0.5 | -8.35 | 3.96E-14 | Crohn's disease |
| UCEC | cis | rs9815354 | 1 | rs6599170 | chr3:41772718 | ULK4 | chr3:41288091-42003660:- | 0.53 | 6.41 | 1.76E-9 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs6599175 | chr3:41786009 | ULK4 | chr3:41288091-42003660:- | -0.51 | -6.27 | 3.57E-9 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs6599176 | chr3:41788492 | ULK4 | chr3:41288091-42003660:- | -0.51 | -6.13 | 7.17E-9 | Diastolic blood pressure |
| UCEC | cis | rs9815354 | 1 | rs6599178 | chr3:41842129 | ULK4 | chr3:41288091-42003660:- | 0.54 | 6.52 | 9.78E-10 | Diastolic blood pressure |